@nagainu_d よく分かりませんが、nsp13、14、15、はINF抑制作用があってp53 はINFα、βが活性化させるようです。 nsp13標的やp53活性化治療薬は開発中みたいですが詳細の分かるのはまだかも🤔 ひょっとしたら新しいmRNAワクチンは標的に入ってる可能性? MDM2阻害剤によるp53活性化 https://t.co/QEapxbt67R
After a brief hiatus, we’re back with another #TeikoTuesday! This week we’re highlighting researchers at @karolinskainst who identified an unexpected target to boost immunotherapy-based treatment of ‘cold’ tumors. https://t.co/DuWqfq6wv3
From the December issue: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity. https://t.co/PwG6Yji5Pp @karolinskainst https://t.co/Sj6KwnBZUF
DRUG TARGETS: preclinical studies have identified a link between TP53 reactivation and increased anti-tumour immunity, mediated by endogenous retrovirus expression; combined MDM2 and immune checkpoint inhibition may be beneficial in the clinic. https://t.c
Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promo… https://t.co/i5X8Kqspv4 https://t.co/V9HUkHGpq5 https://t.co/hJq6hgOf6X
RT @NatRevClinOncol: Pharmacological activation of p53 with the MDM2 inhibitor ALRN-6924 triggers viral mimicry response thereby abolishing…
RT @NatRevClinOncol: Pharmacological activation of p53 with the MDM2 inhibitor ALRN-6924 triggers viral mimicry response thereby abolishing…
Pharmacological activation of p53 with the MDM2 inhibitor ALRN-6924 triggers viral mimicry response thereby abolishing tumour immune evasion and promoting ICI responses in mouse models, with evidence of such an immune response observed in pts with melanoma
Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity https://t.co/9tvCXdcHpY
Galina Selivanova and colleagues publish that p53 activation can boost the immune response to cancers! @MTC_KI #MTCPubs https://t.co/q4VdULLH31
RT @atiqueahmedphd: A new trick for p53: it can stimulate the production of endogenous retroviruses within cancerous cells, prompting an an…
A new trick for p53: it can stimulate the production of endogenous retroviruses within cancerous cells, prompting an anti-tumor immune response. Next Q how this mechanism is altered by mutated p53? #p53 #CancerResearch https://t.co/xEmzxrAyT8
Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity https://t.co/DBfLllqYud
RT @NatRevClinOncol: expression of endogenous retroviruses is a mechanism whereby p53 induction overcomes tumour immune evasion and transfo…
MDM2 inhibitor ALRN-6924 induced a viral mimicry pathway and tumor #inflammation signature genes in melanoma patients. Published in @CD_AACR: https://t.co/atFxrWP6PB https://t.co/AGad0TSS1t
@alanlparker
RT @NatRevClinOncol: expression of endogenous retroviruses is a mechanism whereby p53 induction overcomes tumour immune evasion and transfo…
RT @NatRevClinOncol: expression of endogenous retroviruses is a mechanism whereby p53 induction overcomes tumour immune evasion and transfo…
RT @NatRevClinOncol: expression of endogenous retroviruses is a mechanism whereby p53 induction overcomes tumour immune evasion and transfo…
RT @NatRevClinOncol: expression of endogenous retroviruses is a mechanism whereby p53 induction overcomes tumour immune evasion and transfo…
RT @NatRevClinOncol: expression of endogenous retroviruses is a mechanism whereby p53 induction overcomes tumour immune evasion and transfo…
expression of endogenous retroviruses is a mechanism whereby p53 induction overcomes tumour immune evasion and transforms TME into a favourable phenotype, providing a rationale for synergy of MDM2 inh and immunotherapy https://t.co/scvhRPAmxJ
Scientists from Karolinska Institutet demonstrated how the pharmacological activation of the protein p53 can enhance the immune response to tumors. They believe that their results have important implications for the development of new combination therapies
RT @CD_AACR: #OnlineFirst: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immune evasion and p…
RT @CD_AACR: #OnlineFirst: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immune evasion and p…
Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity. https://t.co/2wtAvVrCeR https://t.co/pYZY87DvPc
RT @CD_AACR: #OnlineFirst: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immune evasion and p…
RT @CD_AACR: #OnlineFirst: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immune evasion and p…
RT @CD_AACR: #OnlineFirst: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immune evasion and p…
RT @CD_AACR: #OnlineFirst: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immune evasion and p…
#OnlineFirst: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity. https://t.co/0rZ0FxI8pW @karolinskainst https://t.co/hiPgEEWziX
RT @ElizSMcKenna: Now online in @CD_AACR: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immun…
Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity https://t.co/VpITtRhDAj
RT @ElizSMcKenna: Now online in @CD_AACR: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immun…
Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity https://t.co/JLfWAjmZPP https://t.co/d2HuDoniff
Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity https://t.co/EKEDY4N7Pk https://t.co/S4jLWIALDf
Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity https://t.co/towrIMz120 https://t.co/LMcStivobT
RT @ElizSMcKenna: Now online in @CD_AACR: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immun…
RT @ElizSMcKenna: Now online in @CD_AACR: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immun…
RT @ElizSMcKenna: Now online in @CD_AACR: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immun…
RT @ElizSMcKenna: Now online in @CD_AACR: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immun…
RT @ElizSMcKenna: Now online in @CD_AACR: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immun…
RT @ElizSMcKenna: Now online in @CD_AACR: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immun…
Now online in @CD_AACR: Pharmacological activation of #p53 triggers #viralmimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity @karolinskainst https://t.co/hVMUN9x7Wq
New article: Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity https://t.co/jnMF5AMv7e #melanoma #oncology https://t.co/acJX40zOEU
MDM2i on the scope again! Astonishing work! https://t.co/I9a1meyWr6
RT @weldeiry: Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-…
Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity | Cancer Discovery https://t.co/OcJ9NnsUsE
Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity | Cancer Discovery https://t.co/Ew1w1Sgzao
Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity https://t.co/1pbkc7gSo2