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American Association for Cancer Research

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Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis

Overview of attention for article published in Molecular Cancer Research, February 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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157 Dimensions

Readers on

mendeley
117 Mendeley
Title
Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis
Published in
Molecular Cancer Research, February 2013
DOI 10.1158/1541-7786.mcr-12-0629
Pubmed ID
Authors

Daniele M. Gilkes, Saumendra Bajpai, Carmen C. Wong, Pallavi Chaturvedi, Maimon E. Hubbi, Denis Wirtz, Gregg L. Semenza

Abstract

Metastasis is the leading cause of death among patients who have breast cancer. Understanding the role of the extracellular matrix (ECM) in the metastatic process may lead to the development of improved therapies to treat patients with cancer. Intratumoral hypoxia, found in the majority of breast cancers, is associated with an increased risk of metastasis and mortality. We found that in hypoxic breast cancer cells, hypoxia-inducible factor 1 (HIF-1) activates transcription of the PLOD1 and PLOD2 genes encoding procollagen lysyl hydroxylases that are required for the biogenesis of collagen, which is a major constituent of the ECM. High PLOD2 expression in breast cancer biopsies is associated with increased risk of mortality. We show that PLOD2 is critical for fibrillar collagen formation by breast cancer cells, increases tumor stiffness, and is required for metastasis to lymph nodes and lungs.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
United Kingdom 1 <1%
Netherlands 1 <1%
Germany 1 <1%
Luxembourg 1 <1%
Poland 1 <1%
Unknown 109 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 33%
Researcher 18 15%
Student > Master 11 9%
Student > Bachelor 10 9%
Student > Doctoral Student 8 7%
Other 18 15%
Unknown 13 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 37 32%
Agricultural and Biological Sciences 30 26%
Medicine and Dentistry 13 11%
Engineering 9 8%
Chemical Engineering 2 2%
Other 8 7%
Unknown 18 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2020.
All research outputs
#1,246,089
of 16,629,244 outputs
Outputs from Molecular Cancer Research
#55
of 1,485 outputs
Outputs of similar age
#17,729
of 253,123 outputs
Outputs of similar age from Molecular Cancer Research
#1
of 13 outputs
Altmetric has tracked 16,629,244 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,485 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,123 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.