| Title |
Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis
|
|---|---|
| Published in |
Molecular Cancer Research, May 2013
|
| DOI | 10.1158/1541-7786.mcr-12-0629 |
| Pubmed ID | |
| Authors |
Daniele M. Gilkes, Saumendra Bajpai, Carmen C. Wong, Pallavi Chaturvedi, Maimon E. Hubbi, Denis Wirtz, Gregg L. Semenza |
| Abstract |
Metastasis is the leading cause of death among patients who have breast cancer. Understanding the role of the extracellular matrix (ECM) in the metastatic process may lead to the development of improved therapies to treat patients with cancer. Intratumoral hypoxia, found in the majority of breast cancers, is associated with an increased risk of metastasis and mortality. We found that in hypoxic breast cancer cells, hypoxia-inducible factor 1 (HIF-1) activates transcription of the PLOD1 and PLOD2 genes encoding procollagen lysyl hydroxylases that are required for the biogenesis of collagen, which is a major constituent of the ECM. High PLOD2 expression in breast cancer biopsies is associated with increased risk of mortality. We show that PLOD2 is critical for fibrillar collagen formation by breast cancer cells, increases tumor stiffness, and is required for metastasis to lymph nodes and lungs. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Luxembourg | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 148 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 26% |
| Researcher | 20 | 13% |
| Student > Master | 18 | 12% |
| Student > Bachelor | 15 | 10% |
| Student > Doctoral Student | 8 | 5% |
| Other | 18 | 12% |
| Unknown | 36 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 46 | 29% |
| Agricultural and Biological Sciences | 31 | 20% |
| Medicine and Dentistry | 13 | 8% |
| Engineering | 11 | 7% |
| Immunology and Microbiology | 4 | 3% |
| Other | 12 | 8% |
| Unknown | 39 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2023.
All research outputs
#1,852,004
of 25,109,675 outputs
Outputs from Molecular Cancer Research
#79
of 2,015 outputs
Outputs of similar age
#14,874
of 198,992 outputs
Outputs of similar age from Molecular Cancer Research
#1
of 16 outputs
Altmetric has tracked 25,109,675 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,015 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,992 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.