Title |
New Perspectives of Curcumin in Cancer Prevention
|
---|---|
Published in |
Cancer Prevention Research, May 2013
|
DOI | 10.1158/1940-6207.capr-12-0410 |
Pubmed ID | |
Authors |
Wungki Park, A.R.M. Ruhul Amin, Zhuo Georgia Chen, Dong M. Shin |
Abstract |
Numerous natural compounds have been extensively investigated for their potential for cancer prevention over the decades. Curcumin, from Curcuma longa, is a highly promising natural compound that can be potentially used for chemoprevention of multiple cancers. Curcumin modulates multiple molecular pathways involved in the lengthy carcinogenesis process to exert its chemopreventive effects through several mechanisms: promoting apoptosis, inhibiting survival signals, scavenging reactive oxidative species (ROS), and reducing the inflammatory cancer microenvironment. Curcumin fulfills the characteristics for an ideal chemopreventive agent with its low toxicity, affordability, and easy accessibility. Nonetheless, the clinical application of curcumin is currently compromised by its poor bioavailability. Here, we review the potential of curcumin in cancer prevention, its molecular targets, and mechanisms of action. Finally, we suggest specific recommendations to improve its efficacy and bioavailability for clinical applications. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 26% |
Spain | 2 | 11% |
Japan | 1 | 5% |
France | 1 | 5% |
Canada | 1 | 5% |
Unknown | 9 | 47% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 13 | 68% |
Practitioners (doctors, other healthcare professionals) | 4 | 21% |
Scientists | 2 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Croatia | 1 | <1% |
Germany | 1 | <1% |
Canada | 1 | <1% |
Unknown | 267 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 43 | 16% |
Student > Bachelor | 41 | 15% |
Student > Ph. D. Student | 22 | 8% |
Student > Postgraduate | 19 | 7% |
Other | 17 | 6% |
Other | 51 | 19% |
Unknown | 79 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 34 | 13% |
Medicine and Dentistry | 33 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 29 | 11% |
Biochemistry, Genetics and Molecular Biology | 26 | 10% |
Chemistry | 18 | 7% |
Other | 49 | 18% |
Unknown | 83 | 31% |