| Title |
Meat and Meat-Mutagen Intake and Pancreatic Cancer Risk in the NIH-AARP Cohort
|
|---|---|
| Published in |
Cancer Epidemiology, Biomarkers & Prevention, December 2007
|
| DOI | 10.1158/1055-9965.epi-07-0378 |
| Pubmed ID | |
| Authors |
Rachael Z. Stolzenberg-Solomon, Amanda J. Cross, Debra T. Silverman, Catherine Schairer, Frances E. Thompson, Victor Kipnis, Amy F. Subar, Albert Hollenbeck, Arthur Schatzkin, Rashmi Sinha |
| Abstract |
Meat intake, particularly red meat, has been positively associated with pancreatic cancer in some epidemiologic studies. Detailed meat-cooking methods and related mutagens formed in meat cooked at high temperatures have not been evaluated prospectively as risk factors for this malignancy. We investigated the association between meat, meat-cooking methods, meat-mutagen intake, and exocrine pancreatic cancer in the NIH-American Association of Retired Persons (NIH-AARP) Diet and Health Study cohort of 537,302 individuals, aged 50 to 71 years, with complete baseline dietary data (1995-1996) ascertained from a food frequency questionnaire. A meat-cooking module was completed by 332,913 individuals 6 months after baseline. During 5 years of follow-up, 836 incident pancreatic cancer cases (555 men, 281 women) were identified. Four hundred and fifty-nine cases had complete meat module data. We used Cox proportional hazard models to calculate hazard ratios (HR) and 95% confidence intervals (CI). Total, red, and high-temperature cooked meat intake was positively associated with pancreatic cancer among men (fifth versus first quintile: HR, 1.41, 95% CI, 1.08-1.83, P trend = 0.001; HR, 1.42, 95% CI, 1.05-1.91, P trend = 0.01; and HR, 1.52, 95% CI, 1.12-2.06, P trend = 0.005, respectively), but not women. Men showed significant 50% increased risks for the highest tertile of grilled/barbecued and broiled meat and significant doubling of risk for the highest quintile of overall meat-mutagenic activity (P trends < 0.01). The fifth quintile of the heterocyclic amine, 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline intake showed a significant 29% (P trend = 0.006) increased risk in men and women combined. These findings support the hypothesis that meat intake, particularly meat cooked at high temperatures and associated mutagens, may play a role in pancreatic cancer development. |
X Demographics
The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 22% |
| United Kingdom | 4 | 13% |
| Spain | 2 | 6% |
| Réunion | 1 | 3% |
| Australia | 1 | 3% |
| France | 1 | 3% |
| Mexico | 1 | 3% |
| Unknown | 15 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 30 | 94% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
| Scientists | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 104 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 14% |
| Student > Ph. D. Student | 14 | 13% |
| Student > Bachelor | 13 | 12% |
| Researcher | 10 | 9% |
| Other | 7 | 7% |
| Other | 21 | 20% |
| Unknown | 26 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 20% |
| Biochemistry, Genetics and Molecular Biology | 16 | 15% |
| Agricultural and Biological Sciences | 14 | 13% |
| Nursing and Health Professions | 10 | 9% |
| Chemistry | 3 | 3% |
| Other | 15 | 14% |
| Unknown | 27 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 183. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2023.
All research outputs
#221,022
of 25,626,416 outputs
Outputs from Cancer Epidemiology, Biomarkers & Prevention
#78
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Outputs of similar age
#437
of 160,199 outputs
Outputs of similar age from Cancer Epidemiology, Biomarkers & Prevention
#1
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