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American Association for Cancer Research

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Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

Overview of attention for article published in Cancer Discovery, May 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

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352 Dimensions

Readers on

mendeley
257 Mendeley
Title
Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance
Published in
Cancer Discovery, May 2014
DOI 10.1158/2159-8290.cd-14-0363
Pubmed ID
Authors

Gizem Karsli-Uzunbas, Jessie Yanxiang Guo, Sandy Price, Xin Teng, Saurabh V Laddha, Sinan Khor, Nada Y. Kalaany, Tyler Jacks, Chang S. Chan, Joshua D. Rabinowitz, Eileen White

Abstract

Macroautophagy (autophagy hereafter) recycles intracellular components to sustain mitochondrial metabolism that promotes the growth, stress tolerance and malignancy of lung cancers, suggesting that autophagy inhibition may have antitumor activity. To assess the functional significance of autophagy in both normal and tumor tissue, we conditionally deleted the essential autophagy gene, autophagy-related-7, Atg7, throughout adult mice. Here we report that systemic ATG7 ablation caused susceptibility to infection and neurodegeneration that limited survival to 2-3 months. Moreover, upon fasting, autophagy-deficient mice suffered fatal hypoglycemia. Prior autophagy ablation did not alter the efficiency of non-small-cell lung cancer (NSCLC) initiation by activation of oncogenic KrasG12D and deletion of the Trp53 tumor suppressor. Acute autophagy ablation in mice with pre-existing NSCLC, however, blocked tumor growth, promoted tumor cell death, and generated more benign disease (oncocytomas). This anti-tumor activity occurred prior to destruction of normal tissues, suggesting that, acute autophagy inhibition may be therapeutically beneficial in cancer.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 257 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Spain 1 <1%
Belgium 1 <1%
Unknown 254 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 55 21%
Researcher 50 19%
Student > Bachelor 30 12%
Student > Master 19 7%
Student > Doctoral Student 11 4%
Other 38 15%
Unknown 54 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 75 29%
Agricultural and Biological Sciences 54 21%
Medicine and Dentistry 29 11%
Pharmacology, Toxicology and Pharmaceutical Science 8 3%
Immunology and Microbiology 6 2%
Other 19 7%
Unknown 66 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2022.
All research outputs
#446,627
of 20,114,180 outputs
Outputs from Cancer Discovery
#218
of 3,217 outputs
Outputs of similar age
#4,946
of 203,460 outputs
Outputs of similar age from Cancer Discovery
#2
of 59 outputs
Altmetric has tracked 20,114,180 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,217 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,460 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.