| Title |
Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China
|
|---|---|
| Published in |
Cancer Prevention Research, August 2014
|
| DOI | 10.1158/1940-6207.capr-14-0103 |
| Pubmed ID | |
| Authors |
Patricia A. Egner, Jian-Guo Chen, Adam T. Zarth, Derek K. Ng, Jin-Bing Wang, Kevin H. Kensler, Lisa P. Jacobson, Alvaro Muñoz, Jamie L. Johnson, John D. Groopman, Jed W. Fahey, Paul Talalay, Jian Zhu, Tao-Yang Chen, Geng-Sun Qian, Steven G. Carmella, Stephen S. Hecht, Thomas W. Kensler |
| Abstract |
Broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can generate the chemopreventive agent, sulforaphane, an inducer of glutathione S-transferases (GSTs) and other cytoprotective enzymes. A broccoli sprout-derived beverage providing daily doses of 600 µmol glucoraphanin and 40 µmol sulforaphane was evaluated for magnitude and duration of pharmacodynamic action in a 12-week randomized clinical trial. Two hundred and ninety-one study participants were recruited from the rural He-He Township, Qidong, in the Yangtze River delta region of China, an area characterized by exposures to substantial levels of airborne pollutants. Exposure to air pollution has been associated with lung cancer and cardiopulmonary diseases. Urinary excretion of the mercapturic acids of the pollutants, benzene, acrolein, and crotonaldehyde, were measured before and during the intervention using liquid chromatography tandem mass spectrometry. Rapid and sustained, statistically significant (p ≤ 0.01) increases in the levels of excretion of the glutathione-derived conjugates of benzene (61%), acrolein (23%), but not crotonaldehyde were found in those receiving broccoli sprout beverage compared with placebo. Excretion of the benzene-derived mercapturic acid was higher in participants who were GSTT1-positive compared to the null genotype, irrespective of study arm assignment. Measures of sulforaphane metabolites in urine indicated that bioavailability did not decline over the 12-week daily dosing period. Thus, intervention with broccoli sprouts enhances the detoxication of some airborne pollutants and may provide a frugal means to attenuate their associated long-term health risks. |
X Demographics
The data shown below were collected from the profiles of 97 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 28 | 29% |
| United Kingdom | 12 | 12% |
| Spain | 7 | 7% |
| Canada | 2 | 2% |
| Germany | 1 | 1% |
| Czechia | 1 | 1% |
| France | 1 | 1% |
| Netherlands | 1 | 1% |
| Belgium | 1 | 1% |
| Other | 6 | 6% |
| Unknown | 37 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 70 | 72% |
| Practitioners (doctors, other healthcare professionals) | 16 | 16% |
| Scientists | 10 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 210 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Japan | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 206 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 45 | 21% |
| Student > Master | 32 | 15% |
| Student > Bachelor | 21 | 10% |
| Student > Ph. D. Student | 20 | 10% |
| Other | 16 | 8% |
| Other | 34 | 16% |
| Unknown | 42 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 53 | 25% |
| Nursing and Health Professions | 19 | 9% |
| Biochemistry, Genetics and Molecular Biology | 18 | 9% |
| Agricultural and Biological Sciences | 18 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 6% |
| Other | 40 | 19% |
| Unknown | 50 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 299. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2024.
All research outputs
#118,421
of 25,753,031 outputs
Outputs from Cancer Prevention Research
#14
of 1,460 outputs
Outputs of similar age
#930
of 241,835 outputs
Outputs of similar age from Cancer Prevention Research
#1
of 24 outputs
Altmetric has tracked 25,753,031 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,460 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,835 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.