| Title |
Lysosomes as Targets for Cancer Therapy
|
|---|---|
| Published in |
Cancer Research, April 2005
|
| DOI | 10.1158/0008-5472.can-05-0476 |
| Pubmed ID | |
| Authors |
Nicole Fehrenbacher, Marja Jäättelä |
| Abstract |
Tumor invasion and metastasis are associated with altered lysosomal trafficking and increased expression of the lysosomal proteases termed cathepsins. Emerging experimental evidence suggests that such alterations in lysosomes may form an "Achilles heel" for cancer cells by sensitizing them to death pathways involving lysosomal membrane permeabilization and the release of cathepsins into the cytosol. Here, we highlight recent results on cancer-related changes in the composition and function of lysosomes, focusing on possible implications for the development of novel cancer therapeutics that target tumor cell lysosomes. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 2 | 2% |
| Netherlands | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 125 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 24% |
| Researcher | 30 | 23% |
| Student > Master | 14 | 11% |
| Student > Bachelor | 10 | 8% |
| Professor > Associate Professor | 7 | 5% |
| Other | 22 | 17% |
| Unknown | 16 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 49 | 38% |
| Chemistry | 20 | 15% |
| Biochemistry, Genetics and Molecular Biology | 20 | 15% |
| Medicine and Dentistry | 11 | 8% |
| Engineering | 5 | 4% |
| Other | 8 | 6% |
| Unknown | 17 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 147. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2021.
All research outputs
#231,781
of 22,768,097 outputs
Outputs from Cancer Research
#102
of 17,867 outputs
Outputs of similar age
#222
of 58,193 outputs
Outputs of similar age from Cancer Research
#2
of 225 outputs
Altmetric has tracked 22,768,097 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,867 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 225 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.