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American Association for Cancer Research

STEAP Proteins: From Structure to Applications in Cancer Therapy

Overview of attention for article published in Molecular Cancer Research, May 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

blogs
1 blog
patent
6 patents

Citations

dimensions_citation
156 Dimensions

Readers on

mendeley
155 Mendeley
citeulike
1 CiteULike
Title
STEAP Proteins: From Structure to Applications in Cancer Therapy
Published in
Molecular Cancer Research, May 2012
DOI 10.1158/1541-7786.mcr-11-0281
Pubmed ID
Authors

Inês M. Gomes, Cláudio J. Maia, Cecília R. Santos

Abstract

The human 6-transmembrane epithelial antigen of prostate (STEAP) family comprises STEAP1, STEAP2, STEAP3, and STEAP4. All of these proteins are unique to mammals and share an innate activity as metalloreductases, indicating their importance in metal metabolism. Overall, they participate in a wide range of biologic processes, such as molecular trafficking in the endocytic and exocytic pathways and control of cell proliferation and apoptosis. STEAP1 and STEAP2 are overexpressed in several types of human cancers, namely prostate, bladder, colon, pancreas, ovary, testis, breast, cervix, and Ewing sarcoma, but their clinical significance and role in cancer cells are not clear. Still, their localization in the cell membrane and differential expression in normal and cancer tissues make STEAP proteins potential candidates as biomarkers of several cancers, as well as potential targets for new immunotherapeutic strategies for disease attenuation or treatment. This review brings together the current knowledge about each STEAP protein, giving an overview of the roles of this family of proteins in human physiology and disease, and analyzes their potential as immunotherapeutic agents in cancer research.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
South Africa 1 <1%
Unknown 153 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 22 14%
Researcher 21 14%
Student > Bachelor 20 13%
Student > Ph. D. Student 20 13%
Other 14 9%
Other 24 15%
Unknown 34 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 25%
Biochemistry, Genetics and Molecular Biology 36 23%
Medicine and Dentistry 18 12%
Pharmacology, Toxicology and Pharmaceutical Science 6 4%
Immunology and Microbiology 4 3%
Other 18 12%
Unknown 35 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2023.
All research outputs
#3,894,511
of 23,578,918 outputs
Outputs from Molecular Cancer Research
#250
of 1,911 outputs
Outputs of similar age
#25,896
of 165,202 outputs
Outputs of similar age from Molecular Cancer Research
#3
of 15 outputs
Altmetric has tracked 23,578,918 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,911 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,202 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.