↓ Skip to main content

American Association for Cancer Research

Article Metrics

STEAP Proteins: From Structure to Applications in Cancer Therapy

Overview of attention for article published in Molecular Cancer Research, April 2012
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

patent
6 patents

Citations

dimensions_citation
94 Dimensions

Readers on

mendeley
122 Mendeley
citeulike
1 CiteULike
Title
STEAP Proteins: From Structure to Applications in Cancer Therapy
Published in
Molecular Cancer Research, April 2012
DOI 10.1158/1541-7786.mcr-11-0281
Pubmed ID
Authors

Inês M. Gomes, Cláudio J. Maia, Cecília R. Santos

Abstract

The human 6-transmembrane epithelial antigen of prostate (STEAP) family comprises STEAP1, STEAP2, STEAP3, and STEAP4. All of these proteins are unique to mammals and share an innate activity as metalloreductases, indicating their importance in metal metabolism. Overall, they participate in a wide range of biologic processes, such as molecular trafficking in the endocytic and exocytic pathways and control of cell proliferation and apoptosis. STEAP1 and STEAP2 are overexpressed in several types of human cancers, namely prostate, bladder, colon, pancreas, ovary, testis, breast, cervix, and Ewing sarcoma, but their clinical significance and role in cancer cells are not clear. Still, their localization in the cell membrane and differential expression in normal and cancer tissues make STEAP proteins potential candidates as biomarkers of several cancers, as well as potential targets for new immunotherapeutic strategies for disease attenuation or treatment. This review brings together the current knowledge about each STEAP protein, giving an overview of the roles of this family of proteins in human physiology and disease, and analyzes their potential as immunotherapeutic agents in cancer research.

Mendeley readers

The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
South Africa 1 <1%
Unknown 120 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 17%
Student > Ph. D. Student 19 16%
Student > Master 19 16%
Other 14 11%
Student > Bachelor 14 11%
Other 23 19%
Unknown 12 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 31%
Biochemistry, Genetics and Molecular Biology 29 24%
Medicine and Dentistry 17 14%
Pharmacology, Toxicology and Pharmaceutical Science 5 4%
Immunology and Microbiology 4 3%
Other 13 11%
Unknown 16 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2021.
All research outputs
#6,370,988
of 19,629,044 outputs
Outputs from Molecular Cancer Research
#532
of 1,678 outputs
Outputs of similar age
#44,834
of 138,177 outputs
Outputs of similar age from Molecular Cancer Research
#7
of 16 outputs
Altmetric has tracked 19,629,044 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,678 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 138,177 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.