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In silico modeling can distinguish functional from benign #MAP2K1 and #MAP2K2 mutants but can’t explain variabilities in #DrugResponse, Hanrahan et al report. @sloan_kettering @AmberKiliti @moriahgabrielle @alexshoushtari @abdelwahablab @DSolit https://t
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Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer https://t.co/C8t4rBPGQk
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Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer https://t.co/nD1PJpRBbn https://t.co/tI79AGtKCk
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Leveraging systematic functional analysis to benchmark an in silico framework distinguishes driver from passenger MEK mutants in #cancer. https://t.co/2elkNkvnFj https://t.co/HaYuQLX3hY
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"Results suggest multifaceted in silico modeling can inform patient accrual to MEK/ERK inhibitor clinical trials, but computational methods need to be paired with laboratory- and clinic-based efforts designed to unravel variabilities in drug response." @al
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RT @CDebyaniPhD: It’s out it’s out it’s out!! Aphrothiti Hanrahan’s & @DSolit’s MEK1/2 @CR_AACR paper. All the characterized variants (& th…
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RT @CDebyaniPhD: It’s out it’s out it’s out!! Aphrothiti Hanrahan’s & @DSolit’s MEK1/2 @CR_AACR paper. All the characterized variants (& th…
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It’s out it’s out it’s out!! Aphrothiti Hanrahan’s & @DSolit’s MEK1/2 @CR_AACR paper. All the characterized variants (& there are A LOT of them) are in @OncoKB (thanks to co-author & @OncoKB Scientist @moriahgabrielle) Such a great paper ->
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RT @moriahgabrielle: Of course Hanrahan’s research is impressive, but I’m just sitting here more impressed that Cancer Res found my elusive…
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RT @moriahgabrielle: Of course Hanrahan’s research is impressive, but I’m just sitting here more impressed that Cancer Res found my elusive…
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Of course Hanrahan’s research is impressive, but I’m just sitting here more impressed that Cancer Res found my elusive Twitter handle. #imnotmad #imimpressed
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RT @NatRevClinOncol: Leveraging systematic functional analysis to benchmark an in silico framework distinguishes driver from passenger MEK…
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RT @NatRevClinOncol: Leveraging systematic functional analysis to benchmark an in silico framework distinguishes driver from passenger MEK…
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Leveraging systematic functional analysis to benchmark an in silico framework distinguishes driver from passenger MEK mutants in cancer: https://t.co/IuCetd6zUs
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Unfortunately we still need to do actual wet lab experiments to learn how to target activating mutations in genes like MAP2K1/MAP2K2. Bio PhD candidates, your jobs are still safe (at least for now). Great work by fellow 🇬🇷 Aphrothiti Hanrahan @DSolit an
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In silico modelling can distinguish functional from benign #MAP2K1 and #MAP2K2 mutants but can’t explain variabilities in #DrugResponse, Hanrahan et al report: https://t.co/lHsmGTiKxV @sloan_kettering @AmberKiliti @moriahgabrielle @alexshoushtari @abdelw