"sertraline inhibits SHMT1/2 activity and glycine uptake, leading to reduced net serine uptake and de novo serine synthesis, to prevent serine accumulation." https://t.co/C4cjghJk6d
https://t.co/3P4FKWidrb "Together, these results support that sertraline inhibits SHMT1/2 activity and glycine uptake, leading to reduced net serine uptake and de novo serine synthesis, to prevent serine accumulation."
https://t.co/3P4FKWidrb "The strength of blocking both the serine into glycine interconversion and glycine uptake is what makes SHMT inhibitors more cytotoxic, explaining sertraline’s potent activity on MDA-MB-468 cells, as was previously also observed us
https://t.co/3P4FKWidrb "Furthermore, measuring glycine uptake and secretion rates revealed that sertraline-treated MDA-MB-468 cells have the tendency to take up less glycine"
https://t.co/3P4FKWidrb "Whether these effects are due to direct serine secretion and/or a sensory feedback mechanism of pyruvate kinase (PKM2), an important regulator of the glycolytic flux, remains to be determined."
https://t.co/3P4FKWidrb "Upon the highest sertraline dose, we even observed net serine secretion." "These observations can explain the lack of serine accumulation in these breast cancer cells."
https://t.co/3P4FKWidrb "To look closer into this, we determined the impact of sertraline on serine/glycine uptake and secretion rates in MDA-MB-468 cells" "Our data showed a dose-dependent reduction of net serine uptake."
https://t.co/3P4FKWidrb "Thimerosal reduces PHGDH activity, while sertraline inhibits SHMT1/2" "In contrast to what may be expected from an SHMT inhibitor, sertraline did not increase the intracellular serine levels"
Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth https://t.co/3P4FKWidrb
RT @renesugar: Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growt…
https://t.co/5cMh96kfcW "Apart from MYC, the oncogene KRAS, the tumor suppressor p53, the mTOR–ATF4 axis, and the T-cell leukemia–associated R98S mutation in ribosomal protein L10 (RPL10 R98S) have also been shown to enhance serine/glycine synthesis in ca
https://t.co/5cMh96kfcW "MYC-driven stimulation of de novo serine synthesis by transcriptional upregulation of PHGDH, PSAT1, and PSPH is also critical for sustaining survival and rapid proliferation of cancer cells under nutrient deprived conditions"
https://t.co/5cMh96kfcW "Besides PHGDH, SHMT2 is also known to be exploited by breast cancer cells as SHMT2 expression levels are positively correlated with breast cancer grade" "Additionally, SHMT2 is identified as a direct target gene of the MYC oncoge
https://t.co/5cMh96kfcW "By relying on intracellular serine/glycine synthesis, cancer cells feed their high requirements to generate formate for purine synthesis, produce reductive equivalents to control redox homeostasis, regulate DNA demethylation, &
https://t.co/5cMh96kfcW "Thereafter, serine is catabolized into glycine, facilitated by serine hydroxymethyltransferase 1 or 2 (SHMT1/2), with 1 and 2 referring to the cell compartment in which the reaction takes place, i.e., the cytosol or the mitochondr
https://t.co/5cMh96kfcW "phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH)."
https://t.co/5cMh96kfcW "De novo serine synthesis branches from glycolysis, with the glycolytic intermediate 3-phosphoglycerate being converted into serine via three consecutive enzymatic reactions catalyzed by phosphoglycerate dehydrogenase (PHGDH),"
Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth https://t.co/5cMh96kfcW
@EwenLescop perhaps of interest: we pointed anticancer actvity of sertraline to SHMT with confirmed affinity at lower micromolar level. https://t.co/SqkJM0B1WN
RRIDs were included in the Molecular Cancer Therapeutics paper "Repurposing the antidepressant sertraline as SHMT…" (https://t.co/nOAcAbKV72). RRIDs like this improve reproducibility in scientific research. #accelerateopenscience #RRID
Serine/glycine synthesis addicted #BreastCancer and T-cell acute #LymphoblasticLeukemia cells are sensitive to #sertraline, highlighting a novel treatment strategy repurposing this #antidepressant for #cancer treatment. @KU_Leuven https://t.co/orII6HqKQr
Serine/glycine synthesis addicted #BreastCancer and T-cell acute #LymphoblasticLeukemia cells are sensitive to #sertraline, highlighting a novel treatment strategy based on repurposing this #antidepressant. @KU_Leuven https://t.co/IwAa0Ep9KC https://t.co/
Serine/glycine synthesis addicted #BreastCancer and T-cell acute #LymphoblasticLeukemia cells are sensitive to #sertraline highlighting a novel treatment strategy repurposing this #antidepressant for #cancer treatment. @KU_Leuven https://t.co/umssEezlVb
RT @DRKAMALAYOUB: اكتشاف خاصية جديدة في الدواء المضاد للاكتئابSertraline والمعروف ايضاً ب Zoloft تحمي الخلايا البشرية من التحول الى خلايا…
Serine/glycine synthesis addicted #BreastCancer and T-cell acute #LymphoblasticLeukemia cells are sensitive to #sertraline, highlighting a novel treatment strategy repurposing this #antidepressant for #cancer treatment. @KU_Leuven https://t.co/DhEUV4yG9m
Serine/glycine synthesis addicted #BreastCancer and T-cell acute #LymphoblasticLeukemia cells are sensitive to #sertraline highlighting a novel treatment strategy repurposing this #antidepressant for #cancer treatment. @KU_Leuven https://t.co/vDYa2UA2gi h
L'antidépresseur sertraline possèderait des propriétés anticancéreuses.... Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth. https://t.co/u40TxCH6aW
#breast #Cancer 🎀🎗️: #sertraline, an #antidepressant, inhibits the production of serine and glycine, essential for tumor growth in #mice 🐁. This reinforces therapeutic strategies by also inhibiting mitochondrial metabolism 🙏 https://t.co/pHzaOPbaEo https:/
RT @DRKAMALAYOUB: اكتشاف خاصية جديدة في الدواء المضاد للاكتئابSertraline والمعروف ايضاً ب Zoloft تحمي الخلايا البشرية من التحول الى خلايا…
#Cancer #sein 🎀🎗️: la #sertraline, un #antidépresseur, inhibe la production de sérine et de glycine, indispensables pour la croissance tumorale chez la #souris 🐁. Une stratégie thérapeutique renforcée en inhibant également le métabolisme mitochondrial 🙏 ht
RT @DRKAMALAYOUB: اكتشاف خاصية جديدة في الدواء المضاد للاكتئابSertraline والمعروف ايضاً ب Zoloft تحمي الخلايا البشرية من التحول الى خلايا…
اكتشاف خاصية جديدة في الدواء المضاد للاكتئابSertraline والمعروف ايضاً ب Zoloft تحمي الخلايا البشرية من التحول الى خلايا سرطانية في الدراسات المخبرية . https://t.co/TfXOxfDFB7
Read the study here: https://t.co/hMz1I6fRPg