46 followers
RT @adammgilbert911: Effects of MTX-23, a PROTAC that degrades AR and AR-V7. Some TGI seen in the Enza resistant 22Rv1 xenograft model #pro…
3,104 followers
Effects of MTX-23, a PROTAC that degrades AR and AR-V7. Some TGI seen in the Enza resistant 22Rv1 xenograft model #proteindegradation #PFEColleague https://t.co/lCUK2gx1JR
4,504 followers
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
1,304 followers
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
1,548 followers
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
12 followers
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
1,002 followers
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
325 followers
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
46 followers
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
43 followers
RT @organischchemie: 右下で発表された阻害剤からPROTACを作成→有効性確認 そもそもの阻害剤の分子量が小さいと PROTACの分子量も小さくなる この感じなら経口でも使える日がくるかもしれない MW of an original cmpd is s…
131 followers
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
3,104 followers
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
5,002 followers
右下で発表された阻害剤からPROTACを作成→有効性確認 そもそもの阻害剤の分子量が小さいと PROTACの分子量も小さくなる この感じなら経口でも使える日がくるかもしれない MW of an original cmpd is small enough to generate a relatively small MTX23 which looks orally available. Great work!
3,957 followers
RT @PDRennert: +1 tip of the PROTAC iceberg. and if you like E3Ligases you're gonna love DUBs !!! https://t.co/0qANlzVxWX
546 followers
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
3,767 followers
RT @PDRennert: +1 tip of the PROTAC iceberg. and if you like E3Ligases you're gonna love DUBs !!! https://t.co/0qANlzVxWX
3,144 followers
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
6,194 followers
+1 tip of the PROTAC iceberg. and if you like E3Ligases you're gonna love DUBs !!!
14,180 followers
Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may open the door to drug the resistance driver in #CRPC. Based on a moderately potent series of AR DBD inhibitors. @AACR @ACSBioMed https
770 followers
Effects of MTX-23, a Novel PROTAC of Androgen Receptor Splice Variant-7 and Androgen Receptor, on CRPC resistant to Second-Line Antiandrogen Therapy. 𝙈𝙤𝙡 𝘾𝙖𝙣𝙘𝙚𝙧 𝙏𝙝𝙚𝙧. #ProstateCancer https://t.co/8eRDMJzcvG
52 followers
Really happy for this!
3,674 followers
Effects of MTX-23, a Novel PROTAC of Androgen Receptor Splice Variant-7 and Androgen Receptor, on CRPC resistant to Second-Line Antiandrogen Therapy https://t.co/IPABn5ZfjB