@Jeff_Mold @NeuralGrndState Our experience with the topic is that the mesenchymal program builds over a pre-existing identity (e.g. https://t.co/X9OJVy5ltF). We tried what you ask here: (e.g. https://t.co/ORirBlxeDG). Check C1 cluster in the supplementary.
@Jeff_Mold @NeuralGrndState We have studied this problem for a few years. I agree there is an oversimplification, but EMT does not exist or is neural crest sound like the opposite oversimplification. In GBM, we made some clear statements, I’d be happy to h
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
Congratulations Gaetano and all involved- awesome paper!
Great job Gaetano !!! Congrats !!!
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
Such a great piece of work, Gaetano! This technology is the way to go to study cell state dynamics…
@anideshpandelab very interesting, in particular the chromatin-enriched proteomics to characterise SGF29 KO. FYI, in 3 genome-wide phenotypic CRISPR KO screen, we found SFG29 as a general barrier to mesenchymal transitions in glioblastoma: https://t.co/X9O
RT @ggargiul_2020: (2/8) We previously showed that creating reporters from complex phenotypes is possible and very helpful to study cancer.…
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @ggargiul_2020: (2/8) We previously showed that creating reporters from complex phenotypes is possible and very helpful to study cancer.…
(2/8) We previously showed that creating reporters from complex phenotypes is possible and very helpful to study cancer. With sLCRs, we reported in @CD_AACR the evidence that innate immune cells directly impart a mesenchymal program in glioblastoma cells:
RT @CD_AACR: May is #braincancerawarenessmonth. Read, Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune…
May is #braincancerawarenessmonth. Read, Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic genetic tracing. @ggargiul_2020 @MDC_Berlin https://t.co/Qh5jPwyUZX https://t.co/WjJpHCUrEG
RT @TaliLev123: Watching the Educational Session: Immunology of Brain Tumors at #AACR21? ICYMI in @CD_AACR: Phenotypic mapping of pathologi…
Watching the Educational Session: Immunology of Brain Tumors at #AACR21? ICYMI in @CD_AACR: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic genetic tracing. @ggargiul_2020 @MDC_Berlin https://t.co/6Yk
Brenda Melano from the PSPG grad program presents https://t.co/yKA0jpNb4c (4/5)
RT @CD_AACR: From the March issue: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic…
From the March issue: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic genetic tracing. @ggargiul_2020 @MDC_Berlin https://t.co/LfWYXfNzXw https://t.co/2R930UtRKS
Phenotypic Mapping of Pathologic Cross-Talk between Glioblastoma and Innate Immune Cells by Synthetic Genetic Tracing https://t.co/LUbJNdHLwO
An interesting study in @CD_AACR uses synthetic genetic tracing to link innate immune cells to mesenchymal transdifferentiation and to study how pharmacological paradigms modulate cell identity in GBM. Great work lead by @ggargiul_2020 https://t.co/fa8lhY7
Phenotypic Mapping of Pathologic Cross-Talk between Glioblastoma and Innate Immune Cells by Synthetic Genetic Tracing https://t.co/lAY68MlSIw
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @ggargiul_2020: (6/7) To discover these factors, we combined CRISPRi screens with our recently published synthetic reporter for EMT (htt…
(6/7) To discover these factors, we combined CRISPRi screens with our recently published synthetic reporter for EMT (https://t.co/K3d4TcC8jj). Our reporter(s) will be soon available to the community through #Addgene, hoping these will be helpful in other s
RT @CD_AACR: ICYMI: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic genetic tracing…
Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracing - Enjoy it! https://t.co/njQYmKVvwM
RT @CD_AACR: ICYMI: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic genetic tracing…
ICYMI: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic genetic tracing. @ggargiul_2020 @MDC_Berlin https://t.co/TQsFkSci6t https://t.co/oaJ0nGs6HK
The original #mdcBerlin press release is available here: https://t.co/cJdJp6X0a6 The paper in @CD_AACR: https://t.co/AqLOFKgBHG @MDC_Berlin @BIMSB_MDC @ggargiul_2020 @ERC_Research @CORDIS_EU
Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracing https://t.co/RnSNtujbCQ
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @CD_AACR: ICYMI: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic genetic tracing…
RT @CD_AACR: ICYMI: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic genetic tracing…
RT @CD_AACR: ICYMI: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic genetic tracing…
RT @CD_AACR: ICYMI: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic genetic tracing…
ICYMI: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic genetic tracing. @ggargiul_2020 @MDC_Berlin #AACRtme21 https://t.co/Nlv1MGd2wI https://t.co/AAtOqtozEx
RT @CD_AACR: Recently published #OnlineFirst: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by…
RT @CD_AACR: Recently published #OnlineFirst: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by…
RT @CD_AACR: Recently published #OnlineFirst: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by…
RT @CD_AACR: Recently published #OnlineFirst: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by…
RT @CD_AACR: Recently published #OnlineFirst: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by…
RT @CD_AACR: Recently published #OnlineFirst: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by…
RT @CD_AACR: Recently published #OnlineFirst: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by…
Recently published #OnlineFirst: Phenotypic mapping of pathological crosstalk between #glioblastoma and innate immune cells by synthetic genetic tracing. @ggargiul_2020 @MDC_Berlin https://t.co/Kgvu2YOkhk https://t.co/lTq9TOa2ve
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracing. https://t.co/oDVzcX5CCT
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @Carlosbionf: Paper out! Thank you to everyone involved! Great work :D @MDC_Berlin @ggargiul_2020 Phenotypic mapping of pathological c…
RT @roserventotormo: Who is who? Check the cell causing the phenotype! An amazing new concept from @Carlosbionf et al.
Who is who? Check the cell causing the phenotype! An amazing new concept from @Carlosbionf et al.
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @Carlosbionf: Paper out! Thank you to everyone involved! Great work :D @MDC_Berlin @ggargiul_2020 Phenotypic mapping of pathological c…
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @CD_AACR: Read the article here: https://t.co/0oXKSLBlFa https://t.co/a0HzMm8svu
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
Read the article here: https://t.co/0oXKSLBlFa
RT @RajKhajur: "... proneural glioblastoma is a hardwired identity, whereas the mesenchymal glioblastoma is an adaptive and metastable cell…
RT @RajKhajur: "... proneural glioblastoma is a hardwired identity, whereas the mesenchymal glioblastoma is an adaptive and metastable cell…
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
Very interesting paper: "Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracing" https://t.co/oEtAZpKVq4
"... proneural glioblastoma is a hardwired identity, whereas the mesenchymal glioblastoma is an adaptive and metastable cell state driven by pro-inflammatory and differentiation cues and DNA damage, but not hypoxia." https://t.co/PuPJD2Gy6j
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracing https://t.co/uT1IhsH0Vp
So great to see this out!!! Congratulations on a beautiful study @ggargiul_2020 and team @MDC_Berlin!
I am very happy that I had the opportunity to give a small contribute to this awesome work from the @ggargiul_2020 lab @MCD_Berlin!! Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracing ht
RT @ggargiul_2020: Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive bra…
Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive brain tumor state, the mesenchymal glioblastoma. Our technology is generally applicable to complex phenotypes! Thanks to the team/funders!
Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracing https://t.co/UfuERgZWbQ Finally out!