#ICYMI - #scFv instability can cause #CAR self-aggregation and tonic signaling. Read here how amino acid substitutions or humanization of the #FWRs abrogate this and enhance #CART functionality. @dokhlab https://t.co/D9mBFWozo2 https://t.co/wN6VN5qBGU
Thank you everyone for wonderful work on novel cancer therapy: Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling https://t.co/AFPlpEt7jo
#scFv instability can cause #CAR self-aggregation and tonic signaling. Read here how amino acid substitutions or humanization of the #FWRs abrogate this and enhance #CART functionality. @dokhlab https://t.co/o8p9PRcqtw https://t.co/m9bvWX4Nn3
RT @dokhlab: Towards a new generation of CAR-T therapy! Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic S…
Towards a new generation of CAR-T therapy! Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling https://t.co/WQe9GmF2wT