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American Association for Cancer Research

Article Metrics

Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis

Overview of attention for article published in Cancer Research, March 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
4 tweeters
patent
2 patents
facebook
1 Facebook page

Citations

dimensions_citation
170 Dimensions

Readers on

mendeley
174 Mendeley
Title
Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Published in
Cancer Research, March 2013
DOI 10.1158/0008-5472.can-12-3963
Pubmed ID
Authors

Daniele M. Gilkes, Pallavi Chaturvedi, Saumendra Bajpai, Carmen C. Wong, Hong Wei, Stephen Pitcairn, Maimon E. Hubbi, Denis Wirtz, Gregg L. Semenza

Abstract

The presence of hypoxia and fibrosis within the primary tumor are two major risk factors for metastasis of human breast cancer. In this study, we demonstrate that hypoxia-inducible factor 1 activates the transcription of genes encoding collagen prolyl hydroxylases that are critical for collagen deposition by breast cancer cells. We show that expression of collagen prolyl hydroxylases promotes cancer cell alignment along collagen fibers, resulting in enhanced invasion and metastasis to lymph nodes and lungs. Finally, we establish the prognostic significance of collagen prolyl hydroxylase mRNA expression in human breast cancer biopsies and show that ethyl 3,4-dihydroxybenzoate, a prolyl hydroxylase inhibitor, decreases tumor fibrosis and metastasis in a mouse model of breast cancer.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 174 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
United States 2 1%
Denmark 1 <1%
Spain 1 <1%
Japan 1 <1%
Russia 1 <1%
Unknown 166 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 53 30%
Student > Master 28 16%
Researcher 26 15%
Student > Bachelor 13 7%
Professor > Associate Professor 8 5%
Other 27 16%
Unknown 19 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 50 29%
Agricultural and Biological Sciences 36 21%
Medicine and Dentistry 25 14%
Engineering 14 8%
Chemistry 10 6%
Other 14 8%
Unknown 25 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2020.
All research outputs
#937,056
of 16,629,244 outputs
Outputs from Cancer Research
#673
of 14,849 outputs
Outputs of similar age
#9,020
of 157,571 outputs
Outputs of similar age from Cancer Research
#12
of 222 outputs
Altmetric has tracked 16,629,244 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,849 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 157,571 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 222 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.