| Title |
Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
|
|---|---|
| Published in |
Cancer Research, May 2013
|
| DOI | 10.1158/0008-5472.can-12-3963 |
| Pubmed ID | |
| Authors |
Daniele M. Gilkes, Pallavi Chaturvedi, Saumendra Bajpai, Carmen C. Wong, Hong Wei, Stephen Pitcairn, Maimon E. Hubbi, Denis Wirtz, Gregg L. Semenza |
| Abstract |
The presence of hypoxia and fibrosis within the primary tumor are two major risk factors for metastasis of human breast cancer. In this study, we demonstrate that hypoxia-inducible factor 1 activates the transcription of genes encoding collagen prolyl hydroxylases that are critical for collagen deposition by breast cancer cells. We show that expression of collagen prolyl hydroxylases promotes cancer cell alignment along collagen fibers, resulting in enhanced invasion and metastasis to lymph nodes and lungs. Finally, we establish the prognostic significance of collagen prolyl hydroxylase mRNA expression in human breast cancer biopsies and show that ethyl 3,4-dihydroxybenzoate, a prolyl hydroxylase inhibitor, decreases tumor fibrosis and metastasis in a mouse model of breast cancer. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 25% |
| United Kingdom | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 234 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| United States | 2 | <1% |
| Russia | 1 | <1% |
| Denmark | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 226 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 61 | 26% |
| Student > Master | 32 | 14% |
| Researcher | 29 | 12% |
| Student > Bachelor | 21 | 9% |
| Professor > Associate Professor | 9 | 4% |
| Other | 31 | 13% |
| Unknown | 51 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 66 | 28% |
| Agricultural and Biological Sciences | 35 | 15% |
| Medicine and Dentistry | 26 | 11% |
| Engineering | 17 | 7% |
| Chemistry | 11 | 5% |
| Other | 21 | 9% |
| Unknown | 58 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2020.
All research outputs
#1,356,208
of 22,760,687 outputs
Outputs from Cancer Research
#919
of 17,849 outputs
Outputs of similar age
#11,968
of 195,188 outputs
Outputs of similar age from Cancer Research
#12
of 278 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,849 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,188 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 278 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.