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American Association for Cancer Research

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Pomegranate Ellagitannin–Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro

Overview of attention for article published in Cancer Prevention Research, January 2010
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#44 of 1,237)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
8 news outlets
blogs
4 blogs
twitter
2 tweeters
patent
2 patents
facebook
2 Facebook pages
video
1 video uploader

Citations

dimensions_citation
133 Dimensions

Readers on

mendeley
105 Mendeley
Title
Pomegranate Ellagitannin–Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro
Published in
Cancer Prevention Research, January 2010
DOI 10.1158/1940-6207.capr-08-0225
Pubmed ID
Authors

Lynn S. Adams, Yanjun Zhang, Navindra P. Seeram, David Heber, Shiuan Chen

Abstract

Estrogen stimulates the proliferation of breast cancer cells and the growth of estrogen-responsive tumors. The aromatase enzyme, which converts androgen to estrogen, plays a key role in breast carcinogenesis. The pomegranate fruit, a rich source of ellagitannins (ET), has attracted recent attention due to its anticancer and antiatherosclerotic properties. On consumption, pomegranate ETs hydrolyze, releasing ellagic acid, which is then converted to 3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one ("urolithin") derivatives by gut microflora. The purpose of this study was to investigate the antiaromatase activity and inhibition of testosterone-induced breast cancer cell proliferation by ET-derived compounds isolated from pomegranates. A panel of 10 ET-derived compounds including ellagic acid, gallagic acid, and urolithins A and B (and their acetylated, methylated, and sulfated analogues prepared in our laboratory) were examined for their ability to inhibit aromatase activity and testosterone-induced breast cancer cell proliferation. Using a microsomal aromatase assay, we screened the panel of ET-derived compounds and identified six with antiaromatase activity. Among these, urolithin B (UB) was shown to most effectively inhibit aromatase activity in a live cell assay. Kinetic analysis of UB showed mixed inhibition, suggesting more than one inhibitory mechanism. Proliferation assays also determined that UB significantly inhibited testosterone-induced MCF-7aro cell proliferation. The remaining test compounds also exhibited antiproliferative activity, but to a lesser degree than UB. These studies suggest that pomegranate ET-derived compounds have potential for the prevention of estrogen-responsive breast cancers.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 <1%
India 1 <1%
Mauritius 1 <1%
Slovenia 1 <1%
Korea, Republic of 1 <1%
Unknown 100 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 18%
Student > Master 18 17%
Student > Bachelor 16 15%
Researcher 13 12%
Student > Doctoral Student 7 7%
Other 17 16%
Unknown 15 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 28%
Medicine and Dentistry 18 17%
Biochemistry, Genetics and Molecular Biology 17 16%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Neuroscience 4 4%
Other 15 14%
Unknown 17 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 88. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2021.
All research outputs
#320,226
of 19,149,304 outputs
Outputs from Cancer Prevention Research
#44
of 1,237 outputs
Outputs of similar age
#2,378
of 168,596 outputs
Outputs of similar age from Cancer Prevention Research
#1
of 23 outputs
Altmetric has tracked 19,149,304 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,237 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,596 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.