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American Association for Cancer Research

Article Metrics

A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells

Overview of attention for article published in Molecular Cancer Therapeutics, September 2006
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#23 of 3,294)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

blogs
2 blogs
twitter
100 tweeters
patent
4 patents
facebook
35 Facebook pages
wikipedia
1 Wikipedia page
googleplus
12 Google+ users

Citations

dimensions_citation
40 Dimensions

Readers on

mendeley
44 Mendeley
Title
A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells
Published in
Molecular Cancer Therapeutics, September 2006
DOI 10.1158/1535-7163.mct-06-0170
Pubmed ID
Authors

Alison J. Butt, Caroline G. Roberts, Alan A. Seawright, Peter B. Oelrichs, John K. MacLeod, Tracy Y.E. Liaw, Maria Kavallaris, Tiffany J. Somers-Edgar, Gillian M. Lehrbach, Colin K. Watts, Robert L. Sutherland

Abstract

Phytochemicals have provided an abundant and effective source of therapeutics for the treatment of cancer. Here we describe the characterization of a novel plant toxin, persin, with in vivo activity in the mammary gland and a p53-, estrogen receptor-, and Bcl-2-independent mode of action. Persin was previously identified from avocado leaves as the toxic principle responsible for mammary gland-specific necrosis and apoptosis in lactating livestock. Here we used a lactating mouse model to confirm that persin has a similar cytotoxicity for the lactating mammary epithelium. Further in vitro studies in a panel of human breast cancer cell lines show that persin selectively induces a G2-M cell cycle arrest and caspase-dependent apoptosis in sensitive cells. The latter is dependent on expression of the BH3-only protein Bim. Bim is a sensor of cytoskeletal integrity, and there is evidence that persin acts as a microtubule-stabilizing agent. Due to the unique structure of the compound, persin could represent a novel class of microtubule-targeting agent with potential specificity for breast cancers.

Twitter Demographics

The data shown below were collected from the profiles of 100 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 2%
South Africa 1 2%
Unknown 42 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 27%
Student > Bachelor 9 20%
Student > Ph. D. Student 6 14%
Researcher 3 7%
Lecturer 2 5%
Other 7 16%
Unknown 5 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 23%
Biochemistry, Genetics and Molecular Biology 7 16%
Chemistry 6 14%
Medicine and Dentistry 6 14%
Engineering 3 7%
Other 3 7%
Unknown 9 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 121. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2021.
All research outputs
#206,448
of 17,994,434 outputs
Outputs from Molecular Cancer Therapeutics
#23
of 3,294 outputs
Outputs of similar age
#1,959
of 178,145 outputs
Outputs of similar age from Molecular Cancer Therapeutics
#1
of 89 outputs
Altmetric has tracked 17,994,434 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,294 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 178,145 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.