| Title |
A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells
|
|---|---|
| Published in |
Molecular Cancer Therapeutics, September 2006
|
| DOI | 10.1158/1535-7163.mct-06-0170 |
| Pubmed ID | |
| Authors |
Alison J. Butt, Caroline G. Roberts, Alan A. Seawright, Peter B. Oelrichs, John K. MacLeod, Tracy Y.E. Liaw, Maria Kavallaris, Tiffany J. Somers-Edgar, Gillian M. Lehrbach, Colin K. Watts, Robert L. Sutherland |
| Abstract |
Phytochemicals have provided an abundant and effective source of therapeutics for the treatment of cancer. Here we describe the characterization of a novel plant toxin, persin, with in vivo activity in the mammary gland and a p53-, estrogen receptor-, and Bcl-2-independent mode of action. Persin was previously identified from avocado leaves as the toxic principle responsible for mammary gland-specific necrosis and apoptosis in lactating livestock. Here we used a lactating mouse model to confirm that persin has a similar cytotoxicity for the lactating mammary epithelium. Further in vitro studies in a panel of human breast cancer cell lines show that persin selectively induces a G2-M cell cycle arrest and caspase-dependent apoptosis in sensitive cells. The latter is dependent on expression of the BH3-only protein Bim. Bim is a sensor of cytoskeletal integrity, and there is evidence that persin acts as a microtubule-stabilizing agent. Due to the unique structure of the compound, persin could represent a novel class of microtubule-targeting agent with potential specificity for breast cancers. |
X Demographics
The data shown below were collected from the profiles of 93 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 20 | 22% |
| Sao Tome and Principe | 1 | 1% |
| Central African Republic | 1 | 1% |
| France | 1 | 1% |
| Unknown | 70 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 93 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 2% |
| South Africa | 1 | 2% |
| Unknown | 56 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 28% |
| Student > Bachelor | 11 | 19% |
| Student > Ph. D. Student | 6 | 10% |
| Researcher | 4 | 7% |
| Student > Doctoral Student | 2 | 3% |
| Other | 9 | 16% |
| Unknown | 10 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 21% |
| Biochemistry, Genetics and Molecular Biology | 8 | 14% |
| Medicine and Dentistry | 7 | 12% |
| Chemistry | 7 | 12% |
| Engineering | 3 | 5% |
| Other | 6 | 10% |
| Unknown | 15 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 120. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2023.
All research outputs
#357,016
of 25,807,758 outputs
Outputs from Molecular Cancer Therapeutics
#36
of 4,099 outputs
Outputs of similar age
#466
of 88,530 outputs
Outputs of similar age from Molecular Cancer Therapeutics
#1
of 47 outputs
Altmetric has tracked 25,807,758 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,099 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.