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American Association for Cancer Research

Article Metrics

Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment

Overview of attention for article published in Cancer Research, August 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
18 news outlets
blogs
4 blogs
twitter
3 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
51 Dimensions

Readers on

mendeley
47 Mendeley
Title
Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment
Published in
Cancer Research, August 2014
DOI 10.1158/0008-5472.can-14-0218
Pubmed ID
Authors

Mary E. Vail, Carmel Murone, April Tan, Linda Hii, Degu Abebe, Peter W. Janes, Fook-Thean Lee, Mark Baer, Varghese Palath, Christopher Bebbington, Geoffrey Yarranton, Carmen Llerena, Slavisa Garic, David Abramson, Glenn Cartwright, Andrew M. Scott, Martin Lackmann

Abstract

Eph receptor tyrosine kinases are critical for cell-cell communication during normal and oncogenic tissue patterning and tumor growth. Somatic mutation profiles of several cancer genomes suggest EphA3 as a tumor suppressor, but its oncogenic expression pattern and role in tumorigenesis remain largely undefined. Here, we report unexpected EphA3 overexpression within the microenvironment of a range of human cancers and mouse tumor xenografts where its activation inhibits tumor growth. EphA3 is found on mouse bone marrow-derived cells with mesenchymal and myeloid phenotypes, and activation of EphA3(+)/CD90(+)/Sca1(+) mesenchymal/stromal cells with an EphA3 agonist leads to cell contraction, cell-cell segregation, and apoptosis. Treatment of mice with an agonistic α-EphA3 antibody inhibits tumor growth by severely disrupting the integrity and function of newly formed tumor stroma and microvasculature. Our data define EphA3 as a novel target for selective ablation of the tumor microenvironment and demonstrate the potential of EphA3 agonists for anticancer therapy. Cancer Res; 74(16); 4470-81. ©2014 AACR.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 4%
United States 1 2%
Germany 1 2%
Unknown 43 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 28%
Student > Ph. D. Student 13 28%
Student > Bachelor 4 9%
Professor > Associate Professor 3 6%
Professor 3 6%
Other 9 19%
Unknown 2 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 32%
Medicine and Dentistry 11 23%
Biochemistry, Genetics and Molecular Biology 7 15%
Pharmacology, Toxicology and Pharmaceutical Science 4 9%
Immunology and Microbiology 2 4%
Other 4 9%
Unknown 4 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 146. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2020.
All research outputs
#148,368
of 16,626,023 outputs
Outputs from Cancer Research
#81
of 14,851 outputs
Outputs of similar age
#1,784
of 203,316 outputs
Outputs of similar age from Cancer Research
#4
of 322 outputs
Altmetric has tracked 16,626,023 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,851 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,316 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 322 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.