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American Association for Cancer Research

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Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

Overview of attention for article published in Molecular Cancer Research, June 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

twitter
8 tweeters
patent
7 patents

Citations

dimensions_citation
190 Dimensions

Readers on

mendeley
333 Mendeley
Title
Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations
Published in
Molecular Cancer Research, June 2015
DOI 10.1158/1541-7786.mcr-15-0203
Pubmed ID
Authors

John C. Hunter, Anuj Manandhar, Martin A. Carrasco, Deepak Gurbani, Sudershan Gondi, Kenneth D. Westover

Abstract

KRAS mutations are the most common genetic abnormalities in cancer but the distribution of specific mutations across cancers and the differential responses of patients with specific KRAS mutations in therapeutic clinical trials suggest that different KRAS mutations have unique biochemical behaviors. To further explain these high-level clinical differences and to explore potential therapeutic strategies for specific KRAS isoforms, we characterized the most common KRAS mutants biochemically for substrate binding kinetics, intrinsic and GTPase-activating protein (GAP) stimulated GTPase activities and interactions with the RAS effector, RAF kinase. Of note, KRAS G13D shows rapid nucleotide exchange kinetics compared to other mutants analyzed. This property can be explained by changes in the electrostatic charge distribution of the active site induced by the G13D mutation as shown by x-ray crystallography. High resolution x-ray structures are also provided for the GDP bound forms of KRAS G12V, G12R and Q61L and reveal additional insight. Overall, the structural data and measurements, obtained herein, indicate that measurable biochemical properties provide clues for identifying KRAS-driven tumors that preferentially signal through RAF. Biochemical profiling and subclassification of KRAS-driven cancers will enable the rational selection of therapies targeting specific KRAS isoforms or specific RAS effectors.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 333 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Germany 2 <1%
Canada 1 <1%
Unknown 327 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 85 26%
Researcher 72 22%
Student > Bachelor 42 13%
Student > Master 35 11%
Other 22 7%
Other 33 10%
Unknown 44 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 134 40%
Agricultural and Biological Sciences 60 18%
Chemistry 41 12%
Pharmacology, Toxicology and Pharmaceutical Science 16 5%
Medicine and Dentistry 12 4%
Other 23 7%
Unknown 47 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2021.
All research outputs
#1,916,248
of 17,060,012 outputs
Outputs from Molecular Cancer Research
#97
of 1,536 outputs
Outputs of similar age
#33,076
of 246,631 outputs
Outputs of similar age from Molecular Cancer Research
#2
of 24 outputs
Altmetric has tracked 17,060,012 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,536 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,631 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.