RT @adammgilbert911: Effects of MTX-23, a PROTAC that degrades AR and AR-V7. Some TGI seen in the Enza resistant 22Rv1 xenograft model #pro…
Effects of MTX-23, a PROTAC that degrades AR and AR-V7. Some TGI seen in the Enza resistant 22Rv1 xenograft model #proteindegradation #PFEColleague https://t.co/lCUK2gx1JR
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
RT @organischchemie: 右下で発表された阻害剤からPROTACを作成→有効性確認 そもそもの阻害剤の分子量が小さいと PROTACの分子量も小さくなる この感じなら経口でも使える日がくるかもしれない MW of an original cmpd is s…
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
右下で発表された阻害剤からPROTACを作成→有効性確認 そもそもの阻害剤の分子量が小さいと PROTACの分子量も小さくなる この感じなら経口でも使える日がくるかもしれない MW of an original cmpd is small enough to generate a relatively small MTX23 which looks orally available. Great work!
RT @PDRennert: +1 tip of the PROTAC iceberg. and if you like E3Ligases you're gonna love DUBs !!! https://t.co/0qANlzVxWX
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
RT @PDRennert: +1 tip of the PROTAC iceberg. and if you like E3Ligases you're gonna love DUBs !!! https://t.co/0qANlzVxWX
RT @HartungIngo: Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may o…
+1 tip of the PROTAC iceberg. and if you like E3Ligases you're gonna love DUBs !!!
Will #PROTACs allow to target so far undruggable disease drivers? MTX-23, an in vivo efficacious degrader for AR-V7, may open the door to drug the resistance driver in #CRPC. Based on a moderately potent series of AR DBD inhibitors. @AACR @ACSBioMed https
Effects of MTX-23, a Novel PROTAC of Androgen Receptor Splice Variant-7 and Androgen Receptor, on CRPC resistant to Second-Line Antiandrogen Therapy. 𝙈𝙤𝙡 𝘾𝙖𝙣𝙘𝙚𝙧 𝙏𝙝𝙚𝙧. #ProstateCancer https://t.co/8eRDMJzcvG
Really happy for this!
Effects of MTX-23, a Novel PROTAC of Androgen Receptor Splice Variant-7 and Androgen Receptor, on CRPC resistant to Second-Line Antiandrogen Therapy https://t.co/IPABn5ZfjB